• Background



Around 1960 ; Picture of old NISSEIKEN headquarters in Tachikawa-city, Tokyo
NISSEIKEN started its business on the land of former army's veterinary material storage facilities.

In April 1947, Nippon Institute for Biological Science (NIBS) as an Incorporated Association was established by famous researchers with the aim of "establishing an ideal world-class private research institute that has never existed in Japanese veterinary society". The philosophy at the time of establishment was "to contribute to the improvement of livestock raising and public health by performing research on livestock health and the prevention of epidemics". The business consisted of researching human and animal diseases, testing disease diagnosis material, as well as researching, manufacturing and selling drugs for animals, agricultural chemicals, herbs, diagnostic agents, vaccines, veterinary medical equipment, and livestock feed.

Shortly after the establishment of the institute, NIBS started research on vaccines and diseases, which were predicted to possibly lead to an epidemic after World War II, such as Japanese encephalitis, rabies, fowl pox, and hog cholera. In 1950, besides the diseases that are caused by a virus infection such as rinderpest, Japanese encephalitis, hog cholera, and rabies, NIBS has uncovered the pathogenesis of diseases such as swine erysipelas, tetanus, and coccidiosis. NIBS has also performed studies on their diagnosis, treatment, and prevention, in addition to development and supply of biologicals for these purposes. NIBS has produced 50 percent of all domestic demand for Japanese encephalitis vaccine, the largest amount of rabies vaccine in Japan, and the maximum feasible amount of hog cholera vaccine. While it was on a small scale, NIBS has also produced vaccines for strangles and distemper, and also therapeutic medicines for osteomalacia, schistosomiasis, and gastrointestinal parasite disease.

In November 1959, NIBS as an Incorporated Association was dissolved, and NIBS as a judicial foundation and Nisseiken Co., Ltd. were newly established. NIBS specialized in pure research and academic activities, and Nisseiken took over the production of conventional veterinary vaccines and the practical application of research results for future development of their business. This reform was carried out to resolve the critical operational problem of two incompatible businesses: the non-profit activity and the profit-seeking activity in the NIBS. Since then, each of them has expanded their business, and devoted themselves to accomplishment of their mission.

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